TISSUE THIAMINE IN HEMORRHAGIC SHOCK 12

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Tissue Thiamine in Hemorrhagic

Govier and his coworkers (1, 2, 3) have stated that dogs previously treated with thiamine withstand hemorrhagic shock better than untreated animals. This observation has not as yet been substantiated by others, but the rise of blood pyruvate and lactate in shock suggests that tissue cocarboxylase (thiaminediphosphate), a coenzyme essential for pyruvate metabolism, may be diminished or inactivat...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1944

ISSN: 0021-9738

DOI: 10.1172/jci101488